In the Spotlight...
Regulatory T-cell sensing of extracellular ATP via P2RX7 promotes their accumulation and suppression and drives lung tumor growth
Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling
Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment
Stochasticity in cancer immunotherapy stems from rare but functionally critical Spark T cells
Previous Digests
BACH2 orchestrates T cell differentiation and can be used to optimize cellular immunotherapies
February 4, 2026
Adoptive T cell transfer (ACT) and CAR-T treatment strategies are limited in their efficacy against solid tumors, as chronic antigen exposure induces exhaustion phenotypes, with reduced proliferation and effector function, limited persistence, and reduced therapeutic efficacy as consequences. Three...
Breaking bad macrophages through remodeling with armored CAR-T
January 28, 2026
CAR T cell efficacy is limited in solid tumors due to their highly immunosuppressive tumor microenvironment (TME), which is partially and often significantly driven by tumor-associated macrophages (TAMs). Various therapies are in development to remodel the TME to improve...
Autocrine RA production feeds back on DC function
January 21, 2026
As professional antigen-presenting cells, dendritic cells have been utilized as whole-cell vaccines, but their clinical efficacy has thus far been limited. Fang et al. found that a common protocol of using GM-CSF and IL-4 to induce bone marrow cells...
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About ACIR
ACIR's mission is to fast-track cancer immunotherapy research by helping researchers stay on top of the new literature in this fast-moving and multifaceted field, fostering their creativity and productivity in bringing us ever closer to curing this deadly disease.
Ute Burkhardt
Ed Fritsch
Lauren Hitchings
Gaëlle Llambi
Maartje Wouters
Alex Najibi
Katherine J. Turner
Stan Wolf
Paula Hochman
Shishir Pant
Nathan Suek
Morgan Janes
TESTIMONIALS
I'm a big fan of ACIR. I enjoy their weekly newsletters with clear, concise, and insightful summaries, complemented by excellent images. I've even used the images in some of my presentations to explain complex cancer immunotherapy findings. In our rapidly evolving field, their reliable and well-curated updates are invaluable.
Richard W. Vague Professor in Immunotherapy; Professor of PL&M; Director, Center for Cellular Immunotherapies; Director, Parker Institute for Cancer Immunotherapy; University of Pennsylvania Perelman School of Medicine. (Supporter since 2025).
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