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Stopping the shredder to unlock a novel source of valuable neoantigens

Inadequate neoantigen presentation in cancer hampers the endogenous antitumor immune response and the efficacy of immunotherapy. One mechanism that limits the production of immune-targetable antigens is nonsense-mediated mRNA decay (NMD)....

Acute and chronic infections drive distinct trajectories in human memory CD4+ T cell formation

Comparing CD4+ T cells generated during acute or chronic hepatitis C virus (HCV) infection, Reinscheid and Weisser et al. evaluated patient samples and found that acute infection generated various sub...

Chemokine-defined macrophage niches establish spatial organization of tumor immunity

Ghosh et al. demonstrated that tissue-resident interstitial macrophages (IMs) and recruited macrophages (recMacs) showed distinct gene expression profiles in B16F10 lung metastases and KPAR1.3 lung tu...

Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion

In a model of chronic LCMV infection, surface phosphatidylserine (PS) expression increased in virus-specific PD-1+CD8+ T cells over time, relative to naive CD8+ T cells and the setting of acute infe...

In vivo generation of CAR myeloid cells through erythrocyte-mediated mRNA delivery for cancer immunotherapy

Nie, Liu, Song, and Yao et al. developed a spleen delivery platform of mRNA-loaded lipid nanoparticles (LNPs) covalently bound to erythrocytes (mRNA-LNP-Ery), which naturally target splenic CD11b+ mye...

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Previous Digests

KEYSTONE SYMPOSIA: Cancer Immunotherapy: Basic Mechanisms Informing Clinical Application

April 8, 2026

The ACIR team attended the Keystone Symposia on Cancer Immunotherapy: Basic Mechanisms Informing Clinical Application held on March 15-18, 2026 in Quebec, QC, Canada. This week’s extensive special feature covers select talks from the conference. We have organized the...

LNP mRNA delivery gets a metabolic boost from amino acid supplement

April 1, 2026

Notice: The article we intended to feature this week was briefly delayed in publication. We will share it with you as soon as the embargo is lifted. In the meantime, we encourage you to revisit last week's feature — it's well...

LNP mRNA delivery gets a metabolic boost from amino acid supplement

March 25, 2026

Lipid nanoparticles (LNPs) have allowed for the delivery of therapeutic mRNA for various therapeutic applications. However, in vivo delivery efficacy is often limited, and research is focused on optimization of LNP formulations. In recent work published in Science Translational...

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ACIR's mission is to fast-track cancer immunotherapy research by helping researchers stay on top of the new literature in this fast-moving and multifaceted field, fostering their creativity and productivity in bringing us ever closer to curing this deadly disease.

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