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No cDC1, no worries: cDC2 and cross-dressing prime T cells in response to mRNA-LNP vaccination

cDC1s play essential roles in CD8+ T cell priming in response to protein- and DNA-based vaccination. However, whether mRNA vaccines function via a similar mechanism remains unknown. In a recent Nature publication, Jo et al. uncovered the mechanisms...

Allogeneic CD19 CAR T cells armed with an anti-rejection CD70 CAR overcome antigen escape and evade alloimmune responses

Aiming to avoid allogeneic CAR-T rejection, Zhang and Li et al. found that a CD70 CAR depleted donor-mismatched, activated (CD70+) T and NK cells in coculture. Dual CD19/CD70 CAR T cells responded to ...

Debio 1562M CD37-targeting ADC is highly active and well tolerated in preclinical models of AML and MDS

Addressing the need for superior toxin delivery and safety for AML and MDS therapies, Marx et al. developed Debio 1562M, a next-generation ADC targeting CD37, which is broadly expressed on AML and MDS...

Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression

Using single-cell and spatial transcriptomics in human and rat models, Bui et al. mapped immune remodeling of normal breast, pre-malignant (DCIS) , and invasive (IBC) breast cancer and identified a pr...

Immune-induced TCR-like antibodies regulate specific T cell response in mice

Kishida et al. showed that immune-induced TCR-like antibodies (iTabs) – antibodies that are specific to an antigen peptide–MHC-II complex – were produced during helper T cell responses to immunizatio...

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Previous Digests

Agonist anti-CD40 converts Tregs from foes to friends

April 22, 2026

Recent investigations into the use of agonist anti-CD40 for cancer immunotherapy have shown that this treatment not only enhances APC functions, but also reduces regulatory T cells (Tregs) within the tumor microenvironment (TME), despite a lack of CD40 on...

Stopping the shredder to unlock a novel source of valuable neoantigens

April 15, 2026

Inadequate neoantigen presentation in cancer hampers the endogenous antitumor immune response and the efficacy of immunotherapy. One mechanism that limits the production of immune-targetable antigens is nonsense-mediated mRNA decay (NMD). NMD degrades transcripts with premature termination codons (PTCs), eliminating...

KEYSTONE SYMPOSIA: Cancer Immunotherapy: Basic Mechanisms Informing Clinical Application

April 8, 2026

The ACIR team attended the Keystone Symposia on Cancer Immunotherapy: Basic Mechanisms Informing Clinical Application held on March 15-18, 2026 in Quebec, QC, Canada. This week’s extensive special feature covers select talks from the conference. We have organized the...

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About ACIR

ACIR's mission is to fast-track cancer immunotherapy research by helping researchers stay on top of the new literature in this fast-moving and multifaceted field, fostering their creativity and productivity in bringing us ever closer to curing this deadly disease.

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