In the Spotlight...
Engineered CCR7 overexpression enhances nodal CAR-T cell homing and cytotoxicity toward B cell lymphoma
Erythrocyte-anti-PD1 conjugates in persons with advanced solid tumors resistant to anti-PD1/PDL1: preclinical characterization and results of a phase 1 trial
Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory
NR2F6 deletion revives CAR-T cell function and induces antigen-agnostic immune memory in solid tumors
Previous Digests
AACR IO 2026
March 4, 2026
The ACIR team attended the AACR IO meeting held on February 18-21, 2026 in Los Angeles, CA, USA. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. T cellsPhilip...
Flt3L fuels DCs to promote ICB-responsive Tpex cells
February 25, 2026
An important predictor of response to immune checkpoint blockade (ICB) is the presence of precursor exhausted T cells (Tpex) in the tumor. Conventional type 1 DCs (cDC1) are known to maintain these Tpex, and modulation of these factors might...
Deep and durable T cell responses after oncolytic viral therapy in glioblastoma
February 18, 2026
In a recent clinical trial, patients with glioblastoma (GBM) were treated with a single dose of an oHSV-1-based oncolytic viral therapy, rQNestin34.5v.2 (CAN-3110, linoserpaturev), in which expression of the viral ICP34.5 gene was controlled by the nestin promoter, overexpressed...
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About ACIR
ACIR's mission is to fast-track cancer immunotherapy research by helping researchers stay on top of the new literature in this fast-moving and multifaceted field, fostering their creativity and productivity in bringing us ever closer to curing this deadly disease.
Ute Burkhardt
Ed Fritsch
Lauren Hitchings
Gaëlle Llambi
Maartje Wouters
Alex Najibi
Katherine J. Turner
Stan Wolf
Paula Hochman
Shishir Pant
Nathan Suek
Morgan Janes
TESTIMONIALS
I'm a big fan of ACIR. I enjoy their weekly newsletters with clear, concise, and insightful summaries, complemented by excellent images. I've even used the images in some of my presentations to explain complex cancer immunotherapy findings. In our rapidly evolving field, their reliable and well-curated updates are invaluable.
Richard W. Vague Professor in Immunotherapy; Professor of PL&M; Director, Center for Cellular Immunotherapies; Director, Parker Institute for Cancer Immunotherapy; University of Pennsylvania Perelman School of Medicine. (Supporter since 2025).
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